History: NASA Archive Photography

On 20 missions (1983–1998) the Space Shuttle carried Spacelab, a space laboratory designed in cooperation with the ESA. Spacelab was not designed for independent orbital flight, but remained in the Shuttle's cargo bay as the astronauts entered and left it through an airlock. Another famous series of missions were the launch and later successful repair of the Hubble space telescope 1990 and 1993
In 1995 Russian-American interaction resumed with the Shuttle-Mir missions (1995–1998). Once more an American vehicle docked with a Russian craft, this time a full-fledged space station. This cooperation has continued to 2011, with Russia and the United States the two biggest partners in the largest space station ever built: the International Space Station (ISS). The strength of their cooperation on this project was even more evident when NASA began relying on Russian launch vehicles to service the ISS during the two-year grounding of the shuttle fleet following the 2003 Space Shuttle Columbia disaster.
The shuttle fleet lost two orbiters and 14 astronauts in two disasters: Challenger in 1986, and Columbia in 2003. While the 1986 loss was mitigated by building the Space Shuttle Endeavour from replacement parts, NASA did not build another orbiter to replace the second loss. NASA's Space Shuttle program had 135 missions when the program ended with the successful landing of the Space Shuttle Atlantis at the Kennedy Space Center on July 21, 2011. The program spanned 30 years with over 300 astronauts sent into space.